Restrictive and hypertrophic cardiomyopathies in Noonan syndrome: the overlap syndromes.
PT Wilmshurst, D Katritsis - Heart, 1996 - heart.bmj.com
PT Wilmshurst, D Katritsis
Heart, 1996•heart.bmj.comA woman with Noonan syndrome had clinical and haemodynamic features of restrictive
cardiomyopathy. There was no ventricular hypertrophy on echocardiography but myocardial
biopsies showed myocyte hypertrophy without pathological disarray. This case illustrates the
overlap of the cardiac phenotypes of Noonan syndrome, restrictive cardiomyopathy, and
hypertrophic cardiomyopathy.
cardiomyopathy. There was no ventricular hypertrophy on echocardiography but myocardial
biopsies showed myocyte hypertrophy without pathological disarray. This case illustrates the
overlap of the cardiac phenotypes of Noonan syndrome, restrictive cardiomyopathy, and
hypertrophic cardiomyopathy.
A woman with Noonan syndrome had clinical and haemodynamic features of restrictive cardiomyopathy. There was no ventricular hypertrophy on echocardiography but myocardial biopsies showed myocyte hypertrophy without pathological disarray. This case illustrates the overlap of the cardiac phenotypes of Noonan syndrome, restrictive cardiomyopathy, and hypertrophic cardiomyopathy.
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