[HTML][HTML] Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling
R Zhao, A Guerrah, H Tang, ZJ Zhao - Journal of Biological Chemistry, 2002 - ASBMB
PZR is an immunoglobulin superfamily cell surface protein containing a pair of
immunoreceptor tyrosine-based inhibitory motifs. As a glycoprotein, PZR displays a strong
association with concanavalin A (ConA), a member of the plant lectin family. Treatment of
several cell lines with ConA caused tyrosine phosphorylation of a major cellular protein.
Immunoblotting and immunoprecipitation studies indicated that this protein corresponded to
PZR. Tyrosine phosphorylation of PZR was accompanied by recruitment of SHP-2 and was …
immunoreceptor tyrosine-based inhibitory motifs. As a glycoprotein, PZR displays a strong
association with concanavalin A (ConA), a member of the plant lectin family. Treatment of
several cell lines with ConA caused tyrosine phosphorylation of a major cellular protein.
Immunoblotting and immunoprecipitation studies indicated that this protein corresponded to
PZR. Tyrosine phosphorylation of PZR was accompanied by recruitment of SHP-2 and was …