[HTML][HTML] Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPα and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation
S Eminaga, AM Bennett - Journal of biological chemistry, 2008 - ASBMB
Noonan syndrome (NS) is an autosomal dominant disorder that is associated with multiple
developmental abnormalities. Activated mutations of the protein-tyrosine phosphatase, SHP-
2/PTPN11, have been reported in∼ 50% of NS cases. Despite being activated, NS-
associated SHP-2 mutants require plasma membrane proximity to evoke disease-
associated signaling. Here we show that NS-associated SHP-2 mutants induce hypertyrosyl
phosphorylation of the transmembrane glycoproteins, SIRPα (signal-regulatory protein α) …
developmental abnormalities. Activated mutations of the protein-tyrosine phosphatase, SHP-
2/PTPN11, have been reported in∼ 50% of NS cases. Despite being activated, NS-
associated SHP-2 mutants require plasma membrane proximity to evoke disease-
associated signaling. Here we show that NS-associated SHP-2 mutants induce hypertyrosyl
phosphorylation of the transmembrane glycoproteins, SIRPα (signal-regulatory protein α) …