SHP2 sails from physiology to pathology
M Tajan, A de Rocca Serra, P Valet, T Edouard… - European journal of …, 2015 - Elsevier
Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been
identified as the causal factor of several developmental diseases (Noonan syndrome (NS),
Noonan syndrome with multiple lentigines (NS-ML), and metachondromatosis), and
malignancies (juvenile myelomonocytic leukemia). SHP2 plays essential physiological
functions in organism development and homeostasis maintenance by regulating …
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been
identified as the causal factor of several developmental diseases (Noonan syndrome (NS),
Noonan syndrome with multiple lentigines (NS-ML), and metachondromatosis), and
malignancies (juvenile myelomonocytic leukemia). SHP2 plays essential physiological
functions in organism development and homeostasis maintenance by regulating …