Interleukin-6 is a key mediator of the hepatoprotective and pro-proliferative effects of ischaemic preconditioning in mice
N Teoh, J Field, G Farrell - Journal of hepatology, 2006 - Elsevier
BACKGROUND/AIMS: The biological effects of ischaemic preconditioning include NF-κB
activation, increased TNF synthesis, stimulation of cell cycle entry and hepatoprotection
against ischaemia-reperfusion (IR) injury. Low dose TNF initiates the priming phase of liver
regeneration via NF-κB and IL-6. To determine whether (1) IL-6 is released during
preconditioning and confers protection against hepatic IR injury, and (2) IL-6 could mediate
the biological effects of preconditioning. METHODS: Wildtype (wt) and TNF−/− C57BL6 mice …
activation, increased TNF synthesis, stimulation of cell cycle entry and hepatoprotection
against ischaemia-reperfusion (IR) injury. Low dose TNF initiates the priming phase of liver
regeneration via NF-κB and IL-6. To determine whether (1) IL-6 is released during
preconditioning and confers protection against hepatic IR injury, and (2) IL-6 could mediate
the biological effects of preconditioning. METHODS: Wildtype (wt) and TNF−/− C57BL6 mice …