Background & Aims Biliary atresia (BA) results from a neonatal inflammatory and fibrosing
obstruction of bile ducts of unknown etiology. Although the innate immune system has been
linked to the virally induced mechanism of disease, the role of inflammasome-mediated
epithelial injury remains largely undefined. Here, we hypothesized that disruption of the
inflammasome suppresses the neonatal proinflammatory response and prevents
experimental BA. Methods We determined the expression of key inflammasome-related …