Thymus transplantation
ML Markert, BH Devlin, EA McCarthy - Clinical immunology, 2010 - Elsevier
Thymus transplantation is a promising investigational therapy for infants born with no
thymus. Because of the athymia, these infants lack T cell development and have a severe
primary immunodeficiency. Although thymic hypoplasia or aplasia is characteristic of
DiGeorge anomaly, in “complete” DiGeorge anomaly, there is no detectable thymus as
determined by the absence of naive (CD45RA+, CD62L+) T cells. Transplantation of
postnatal allogeneic cultured thymus tissue was performed in sixty subjects with complete …
thymus. Because of the athymia, these infants lack T cell development and have a severe
primary immunodeficiency. Although thymic hypoplasia or aplasia is characteristic of
DiGeorge anomaly, in “complete” DiGeorge anomaly, there is no detectable thymus as
determined by the absence of naive (CD45RA+, CD62L+) T cells. Transplantation of
postnatal allogeneic cultured thymus tissue was performed in sixty subjects with complete …
