[HTML][HTML] Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
U Diczfalusy, KE Olofsson, AM Carlsson, M Gong… - Journal of lipid …, 2009 - ASBMB
During screening of genes upregulated by lipopolysaccharide (LPS; endotoxin) treatment of
bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-
hydroxylase (Ch25h) was strongly upregulated. Treatment of macrophages with 10 ng/ml of
LPS for 2 h resulted in a 35-fold increase in the expression of Ch25h. In contrast, LPS
treatment did not increase the expression of Cyp27a1 or Cyp7b1. The increased Ch25h
expression was found to be independent of Myeloid differentiation protein 88 signaling but …
bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-
hydroxylase (Ch25h) was strongly upregulated. Treatment of macrophages with 10 ng/ml of
LPS for 2 h resulted in a 35-fold increase in the expression of Ch25h. In contrast, LPS
treatment did not increase the expression of Cyp27a1 or Cyp7b1. The increased Ch25h
expression was found to be independent of Myeloid differentiation protein 88 signaling but …