Comparison of experimental protocols of physical exercise for mdx mice and Duchenne muscular dystrophy patients
J Hyzewicz, UT Ruegg… - Journal of neuromuscular …, 2015 - content.iospress.com
J Hyzewicz, UT Ruegg, S Takeda
Journal of neuromuscular diseases, 2015•content.iospress.comAbstract Duchenne Muscular Dystrophy (DMD) is caused by mutations in the gene coding
for dystrophin and leads to muscle degeneration, wheelchair dependence and death by
cardiac or respiratory failure. Physical exercise has been proposed as a palliative therapy
for DMD to maintain muscle strength and prevent contractures for as long as possible.
However, its practice remains controversial because the benefits of training may be
counteracted by muscle overuse and damage.
for dystrophin and leads to muscle degeneration, wheelchair dependence and death by
cardiac or respiratory failure. Physical exercise has been proposed as a palliative therapy
for DMD to maintain muscle strength and prevent contractures for as long as possible.
However, its practice remains controversial because the benefits of training may be
counteracted by muscle overuse and damage.
Abstract
Duchenne Muscular Dystrophy (DMD) is caused by mutations in the gene coding for dystrophin and leads to muscle degeneration, wheelchair dependence and death by cardiac or respiratory failure. Physical exercise has been proposed as a palliative therapy for DMD to maintain muscle strength and prevent contractures for as long as possible. However, its practice remains controversial because the benefits of training may be counteracted by muscle overuse and damage.
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