Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore–induced allergic airway disease

AP Moreira, KA Cavassani, R Hullinger… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Aspergillus fumigatus conidia aggravate asthmatic responses. Lung
macrophages normally kill fungal conidia, but the presence of type 2 cytokines during
asthma contributes to the alternative (or M2) activation of these cells, which secrete
proallergic factors and exhibit impaired innate immunity. OBJECTIVE: Considering that
pentraxins modulate macrophage function, we examined the effect of C-reactive protein
(CRP) and serum amyloid P (SAP) in an experimental model of A fumigatus–induced …