The pathogenesis of hypertension is multi-factorial, involving many of the systems
contributing to blood pressure homeostasis including the vasculature, kidneys, central, and
sympathetic nervous systems, along with various hormonal regulators. However, over the
years, many studies have indicated a predominant importance of the kidney in blood
pressure homeostasis and hypertension. This work has established the notion that the
kidney is a key determinant of the chronic level of intra-arterial pressure playing a major role …