In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers
T Kikuchi, M Hassanein, JM Amann, Q Liu… - Molecular & Cellular …, 2012 - ASBMB
Advances in proteomic analysis of human samples are driving critical aspects of biomarker
discovery and the identification of molecular pathways involved in disease etiology. Toward
that end, in this report we are the first to use a standardized shotgun proteomic analysis
method for in-depth tissue protein profiling of the two major subtypes of nonsmall cell lung
cancer and normal lung tissues. We identified 3621 proteins from the analysis of pooled
human samples of squamous cell carcinoma, adenocarcinoma, and control specimens. In …
discovery and the identification of molecular pathways involved in disease etiology. Toward
that end, in this report we are the first to use a standardized shotgun proteomic analysis
method for in-depth tissue protein profiling of the two major subtypes of nonsmall cell lung
cancer and normal lung tissues. We identified 3621 proteins from the analysis of pooled
human samples of squamous cell carcinoma, adenocarcinoma, and control specimens. In …
