[HTML][HTML] A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression
CP Larsen, SJ Knechtle, A Adams, T Pearson… - American journal of …, 2006 - Elsevier
Activated T cells orchestrate the immune response that results in graft rejection; therefore, a
common goal among current immunosuppressive therapies is to block T-cell activation,
proliferation and function. Current immunosuppressive regimens that inhibit T cells and
immune cells have greatly reduced the incidence of acute rejection following solid-organ
transplant. However, the expected improvements in long-term outcomes have not been
realized. This may be related to the non-immune side effects of current maintenance …
common goal among current immunosuppressive therapies is to block T-cell activation,
proliferation and function. Current immunosuppressive regimens that inhibit T cells and
immune cells have greatly reduced the incidence of acute rejection following solid-organ
transplant. However, the expected improvements in long-term outcomes have not been
realized. This may be related to the non-immune side effects of current maintenance …
