Publisher Summary The coumermycin-GyrB system is a useful strategy for regulating protein
homodimerization and activation both in cell extracts and in intact cell culture systems.
Coumermycin-based dimerization strategies are currently being used to identify biological
responses (such as changes in gene transcription) induced by the Raf and Jak/signal
transducers and activators of transcription (STAT) signal transduction pathways. As the utility
of dimerization-based strategies becomes evident, they are applied to an increasing number …