Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodies
ELV Silveira, SP Kasturi, Y Kovalenkov… - Journal of …, 2015 - Elsevier
Over 100 broadly neutralizing antibodies have been isolated from a minority of HIV infected
patients, but the steps leading to the selection of plasma cells producing such antibodies
remain incompletely understood, hampering the development of vaccines able to elicit them.
Rhesus macaques have become a preferred animal model system used to study SIV/HIV, for
the characterization and development of novel therapeutics and vaccines as well as to
understand pathogenesis. However, most of our knowledge about the dynamics of antibody …
patients, but the steps leading to the selection of plasma cells producing such antibodies
remain incompletely understood, hampering the development of vaccines able to elicit them.
Rhesus macaques have become a preferred animal model system used to study SIV/HIV, for
the characterization and development of novel therapeutics and vaccines as well as to
understand pathogenesis. However, most of our knowledge about the dynamics of antibody …