Variable lymphocyte receptor (VLR) B antibodies of the evolutionary distant sea lamprey are
structurally distinct from conventional mammalian antibodies. The different protein
architecture and large evolutionary distance of jawless vertebrates suggest that VLR
antibodies may represent promising tools for biomarker discovery. Here we report the
generation of panels of monoclonal VLR antibodies from lamprey larvae immunized with
human T cells and the use of a recombinant monoclonal VLR antibody for antigen …