[HTML][HTML] Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase
LA Tintignac, J Lagirand, S Batonnet, V Sirri… - Journal of Biological …, 2005 - ASBMB
MyoD controls myoblast identity and differentiation and is required for myogenic stem cell
function in adult skeletal muscle. MyoD is degraded by the ubiquitin-proteasome pathway
mediated by different E3 ubiquitin ligases not identified as yet. Here we report that MyoD
interacts with Atrogin-1/MAFbx (MAFbx), a striated muscle-specific E3 ubiquitin ligase
dramatically up-regulated in atrophying muscle. A core LXXLL motif sequence in MyoD is
necessary for binding to MAFbx. MAFbx associates with MyoD through an inverted LXXLL …
function in adult skeletal muscle. MyoD is degraded by the ubiquitin-proteasome pathway
mediated by different E3 ubiquitin ligases not identified as yet. Here we report that MyoD
interacts with Atrogin-1/MAFbx (MAFbx), a striated muscle-specific E3 ubiquitin ligase
dramatically up-regulated in atrophying muscle. A core LXXLL motif sequence in MyoD is
necessary for binding to MAFbx. MAFbx associates with MyoD through an inverted LXXLL …