[HTML][HTML] Recombinant human MFG-E8 ameliorates colon damage in DSS-and TNBS-induced colitis in mice
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive
system and typically requires lifelong medical care. Recombinant human MFG-E8 (rhMFG-
E8) is a 364-amino acid protein, which promotes apoptotic cell clearance and reduces
inflammation. This study investigates the therapeutic effect of rhMFG-E8 on two well-
established mouse models of IBD. Acute mucosal injury leading to colitis was caused by
exposing C57BL/6 mice to 4% dextran sodium sulfate (DSS) in the drinking water over 7 …
system and typically requires lifelong medical care. Recombinant human MFG-E8 (rhMFG-
E8) is a 364-amino acid protein, which promotes apoptotic cell clearance and reduces
inflammation. This study investigates the therapeutic effect of rhMFG-E8 on two well-
established mouse models of IBD. Acute mucosal injury leading to colitis was caused by
exposing C57BL/6 mice to 4% dextran sodium sulfate (DSS) in the drinking water over 7 …