[HTML][HTML] Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family

X De Deken, D Wang, MC Many, S Costagliola… - Journal of Biological …, 2000 - ASBMB
Two cDNAs encoding NADPH oxidases and constituting the thyroid H 2 O 2 generating
system have been cloned. The strategy of cloning was based on the functional similarities
between H 2 O 2 generation in leukocytes and the thyroid, according to the hypothesis that
one of the components of the thyroid system would belong to the gp91 Phox/Mox1 gene
family and display sequence similarities with gp91 Phox. Screening at low stringency with a
gp91 Phox probe of cDNA libraries from thyroid cells in primary culture yielded two distinct …