[HTML][HTML] The NADPH oxidases DUOX1 and NOX2 play distinct roles in redox regulation of epidermal growth factor receptor signaling

DE Heppner, M Hristova, CM Dustin, K Danyal… - Journal of Biological …, 2016 - ASBMB
The epidermal growth factor receptor (EGFR) plays a critical role in regulating airway
epithelial homeostasis and responses to injury. Activation of EGFR is regulated by redox-
dependent processes involving reversible cysteine oxidation by reactive oxygen species
(ROS) and involves both ligand-dependent and-independent mechanisms, but the precise
source (s) of ROS and the molecular mechanisms that control tyrosine kinase activity are
incompletely understood. Here, we demonstrate that stimulation of EGFR activation by ATP …