Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33
CA Christianson, NP Goplen, I Zafar, C Irvin… - Journal of Allergy and …, 2015 - Elsevier
Background Asthma in a mouse model spontaneously resolves after cessation of allergen
exposure. We developed a mouse model in which asthma features persisted for 6 months
after cessation of allergen exposure. Objective We sought to elucidate factors contributing to
the persistence of asthma. Methods We used a combination of immunologic, genetic,
microarray, and pharmacologic approaches to dissect the mechanism of asthma
persistence. Results Elimination of T cells though antibody-mediated depletion or lethal …
exposure. We developed a mouse model in which asthma features persisted for 6 months
after cessation of allergen exposure. Objective We sought to elucidate factors contributing to
the persistence of asthma. Methods We used a combination of immunologic, genetic,
microarray, and pharmacologic approaches to dissect the mechanism of asthma
persistence. Results Elimination of T cells though antibody-mediated depletion or lethal …