Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways
CA Wu, JJ Peluso, L Zhu, EG Lingenheld, ST Walker… - Cellular …, 2010 - Elsevier
IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While
naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5
in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with
OVA-induced allergic airway disease (AAD), produced elevated levels of IL-5 mRNA and
protein as compared to BEC from naïve mice. To determine the contribution of BEC-derived
IL-5 to effector responses in the airways, IL-5 deficient bone marrow chimeric mice were …
naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5
in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with
OVA-induced allergic airway disease (AAD), produced elevated levels of IL-5 mRNA and
protein as compared to BEC from naïve mice. To determine the contribution of BEC-derived
IL-5 to effector responses in the airways, IL-5 deficient bone marrow chimeric mice were …