Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses
M Hristova, A Habibovic, C Veith… - Journal of Allergy and …, 2016 - Elsevier
Background The IL-1 family member IL-33 plays a critical role in type 2 innate immune
responses to allergens and is an important mediator of allergic asthma. The mechanisms by
which allergens provoke epithelial IL-33 secretion are still poorly understood. Objective
Based on previous findings indicating involvement of the NADPH oxidase dual oxidase 1
(DUOX1) in epithelial wound responses, we explored the potential involvement of DUOX1 in
allergen-induced IL-33 secretion and potential alterations in airways of asthmatic patients …
responses to allergens and is an important mediator of allergic asthma. The mechanisms by
which allergens provoke epithelial IL-33 secretion are still poorly understood. Objective
Based on previous findings indicating involvement of the NADPH oxidase dual oxidase 1
(DUOX1) in epithelial wound responses, we explored the potential involvement of DUOX1 in
allergen-induced IL-33 secretion and potential alterations in airways of asthmatic patients …