[HTML][HTML] Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes
J Pacheco-Quinto, EA Eckman - Journal of Biological Chemistry, 2013 - ASBMB
Impairments in Aβ removal are increasingly being considered as a possible cause for the
abnormal Aβ build-up typical of Alzheimer disease. Of particular interest is a pool of Aβ that
accumulates intraneuronally and may contribute to neuronal toxicity. The mechanism for
intraneuronal accumulation, however, is not well understood and is commonly attributed to
impaired removal of extracellular Aβ by neurons. Based on the intracellular distribution of
the well established Aβ degrading enzymes, ECE-1 and ECE-2, we tested whether …
abnormal Aβ build-up typical of Alzheimer disease. Of particular interest is a pool of Aβ that
accumulates intraneuronally and may contribute to neuronal toxicity. The mechanism for
intraneuronal accumulation, however, is not well understood and is commonly attributed to
impaired removal of extracellular Aβ by neurons. Based on the intracellular distribution of
the well established Aβ degrading enzymes, ECE-1 and ECE-2, we tested whether …
