Short‐and long‐term effects of endurance training in patients with mitochondrial myopathy
TD Jeppesen, M Dunø, M Schwartz… - European journal of …, 2009 - Wiley Online Library
TD Jeppesen, M Dunø, M Schwartz, T Krag, J Rafiq, F Wibrand, J Vissing
European journal of neurology, 2009•Wiley Online LibraryBackground and purpose: It is unknown whether prolonged training is a safe treatment to
alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.
Methods: The effect of 3 and 12 months training and 3–12 months deconditioning was
studied in four patients carrying different mtDNA mutations. Results: Three‐month moderate‐
intensity training increased oxidative capacity by 23%, which was sustained after 6–12
months of low‐intensity training. Training and deconditioning did not induce adverse effects …
alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.
Methods: The effect of 3 and 12 months training and 3–12 months deconditioning was
studied in four patients carrying different mtDNA mutations. Results: Three‐month moderate‐
intensity training increased oxidative capacity by 23%, which was sustained after 6–12
months of low‐intensity training. Training and deconditioning did not induce adverse effects …
Background and purpose: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.
Methods: The effect of 3 and 12 months training and 3–12 months deconditioning was studied in four patients carrying different mtDNA mutations.
Results: Three‐month moderate‐intensity training increased oxidative capacity by 23%, which was sustained after 6–12 months of low‐intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.
Conclusion: Long‐term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.
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