Functional and phenotypic heterogeneity of group 3 innate lymphoid cells
F Melo‐Gonzalez, MR Hepworth - Immunology, 2017 - Wiley Online Library
Immunology, 2017•Wiley Online Library
Group 3 innate lymphoid cells (ILC 3), defined by expression of the transcription factor
retinoid‐related orphan receptor γt, play key roles in the regulation of inflammation and
immunity in the gastrointestinal tract and associated lymphoid tissues. ILC 3 consist largely
of two major subsets, NCR+ ILC 3 and LT i‐like ILC 3, but also demonstrate significant
plasticity and heterogeneity. Recent advances have begun to dissect the relationship
between ILC 3 subsets and to define distinct functional states within the intestinal tissue …
retinoid‐related orphan receptor γt, play key roles in the regulation of inflammation and
immunity in the gastrointestinal tract and associated lymphoid tissues. ILC 3 consist largely
of two major subsets, NCR+ ILC 3 and LT i‐like ILC 3, but also demonstrate significant
plasticity and heterogeneity. Recent advances have begun to dissect the relationship
between ILC 3 subsets and to define distinct functional states within the intestinal tissue …
Summary
Group 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid‐related orphan receptor γt, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR+ ILC3 and LTi‐like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever‐expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation – with a focus on comparing and contrasting the relative contributions of ILC3 subsets.
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