[HTML][HTML] BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes
A Ehlers, W Xie, E Agapov, S Brown, D Steinberg… - Mucosal …, 2018 - Elsevier
Patients with asthma experience circadian variations in their symptoms. However it remains
unclear how specific aspects of this common airway disease relate to clock genes, which are
critical to the generation of circadian rhythms in mammals. Here, we used a viral model of
acute and chronic airway disease to examine how circadian clock disruption affects
asthmatic lung phenotypes. Deletion of the core clock gene bmal1 or environmental
disruption of circadian function by jet lag exacerbated acute viral bronchiolitis caused by …
unclear how specific aspects of this common airway disease relate to clock genes, which are
critical to the generation of circadian rhythms in mammals. Here, we used a viral model of
acute and chronic airway disease to examine how circadian clock disruption affects
asthmatic lung phenotypes. Deletion of the core clock gene bmal1 or environmental
disruption of circadian function by jet lag exacerbated acute viral bronchiolitis caused by …