How cigarette smoke skews immune responses to promote infection, lung disease and cancer

MR Stämpfli, GP Anderson - Nature Reviews Immunology, 2009 - nature.com
Nature Reviews Immunology, 2009nature.com
A complex and multilayered immune defence system protects the host against harmful
agents and maintains tissue homeostasis. Cigarette smoke ex posure markedly impacts the
immune system, compromising the host's ability to mount appropriate immune and
inflammatory responses and contributing to smoking-related pathologies. These adverse
effects on the immune system not only occur in active smokers, but also in those exposed to
smoke passively in contaminated environments, and may persist for decades after exposure …
Abstract
A complex and multilayered immune defence system protects the host against harmful agents and maintains tissue homeostasis. Cigarette smoke ex posure markedly impacts the immune system, compromising the host's ability to mount appropriate immune and inflammatory responses and contributing to smoking-related pathologies. These adverse effects on the immune system not only occur in active smokers, but also in those exposed to smoke passively in contaminated environments, and may persist for decades after exposure has ended.
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