Fructose metabolism and metabolic disease

SA Hannou, DE Haslam, NM McKeown… - The Journal of …, 2018 - Am Soc Clin Investig
The Journal of clinical investigation, 2018Am Soc Clin Investig
Increased sugar consumption is increasingly considered to be a contributor to the worldwide
epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of
its unique metabolic properties, the fructose component of sugar may be particularly harmful.
Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome.
Here we review the biology of fructose metabolism as well as potential mechanisms by
which excessive fructose consumption may contribute to cardiometabolic disease.
Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.
The Journal of Clinical Investigation