The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathy: potential role in glomerular hypertrophy.
CJ Kuan, M Al-Douahji… - Journal of the American …, 1998 - journals.lww.com
High glucose inhibits mesangial cell proliferation in vitro and induces hypertrophy in
mesangial cells in culture and in experimental diabetic nephropathy. Cell growth is
ultimately controlled at the level of the cell cycle by cell cycle regulatory proteins. Cell cycle
progression requires that cyclin-dependent kinases be activated by cyclins. Cyclin kinase
inhibitors (CKI) inactivate cyclin-dependent kinases, causing cell cycle arrest. In the current
study, high glucose-induced mesangial cell hypertrophy in vitro is shown to be associated …
mesangial cells in culture and in experimental diabetic nephropathy. Cell growth is
ultimately controlled at the level of the cell cycle by cell cycle regulatory proteins. Cell cycle
progression requires that cyclin-dependent kinases be activated by cyclins. Cyclin kinase
inhibitors (CKI) inactivate cyclin-dependent kinases, causing cell cycle arrest. In the current
study, high glucose-induced mesangial cell hypertrophy in vitro is shown to be associated …