Genome-wide analysis of Wilms' tumor 1-controlled gene expression in podocytes reveals key regulatory mechanisms
M Kann, S Ettou, YL Jung, MO Lenz… - Journal of the …, 2015 - journals.lww.com
The transcription factor Wilms' tumor suppressor 1 (WT1) is key to podocyte development
and viability; however, WT1 transcriptional networks in podocytes remain elusive. We
provide a comprehensive analysis of the genome-wide WT1 transcriptional network in
podocytes in vivo using chromatin immunoprecipitation followed by sequencing (ChIPseq)
and RNA sequencing techniques. Our data show a specific role for WT1 in regulating the
podocyte-specific transcriptome through binding to both promoters and enhancers of target …
and viability; however, WT1 transcriptional networks in podocytes remain elusive. We
provide a comprehensive analysis of the genome-wide WT1 transcriptional network in
podocytes in vivo using chromatin immunoprecipitation followed by sequencing (ChIPseq)
and RNA sequencing techniques. Our data show a specific role for WT1 in regulating the
podocyte-specific transcriptome through binding to both promoters and enhancers of target …