CTLA-4 can function as a negative regulator of T cell activation
TL Walunas, DJ Lenschow, CY Bakker, PS Linsley… - Immunity, 1994 - cell.com
Immunity, 1994•cell.com
CD28 and CTLA-4 are related glycoproteins found on T cells. Ligation of CD28 following
antigen receptor engagement provides a costimulatory signal required for T cell activation.
Anti-CTLA-4 antibodies were generated to examine the role of the CTLA-4 receptor on
murine T cells. Expression of CTLA4 as a homodimer is up-regulated 2-3 days following T
cell activation. Anti-CTLA-4 antlbodies and Fab fragments augmented T cell proliferation In
an allogeneic MLR. However, when optimal costimulation and Fc cross-linking were …
antigen receptor engagement provides a costimulatory signal required for T cell activation.
Anti-CTLA-4 antibodies were generated to examine the role of the CTLA-4 receptor on
murine T cells. Expression of CTLA4 as a homodimer is up-regulated 2-3 days following T
cell activation. Anti-CTLA-4 antlbodies and Fab fragments augmented T cell proliferation In
an allogeneic MLR. However, when optimal costimulation and Fc cross-linking were …
CD28 and CTLA-4 are related glycoproteins found on T cells. Ligation of CD28 following antigen receptor engagement provides a costimulatory signal required for T cell activation. Anti-CTLA-4 antibodies were generated to examine the role of the CTLA-4 receptor on murine T cells. Expression of CTLA4 as a homodimer is up-regulated 2-3 days following T cell activation. Anti-CTLA-4 antlbodies and Fab fragments augmented T cell proliferation In an allogeneic MLR. However, when optimal costimulation and Fc cross-linking were present, anti-CTLA-4 MAbs Inhibited T cell prollferatlon. Together, these results suggest that the MAb may obstruct the interaction of CTLA-4 with Its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function.
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