Pluripotent stem cells as a robust source of mesenchymal stem cells

CD Luzzani, SG Miriuka - Stem cell reviews and reports, 2017 - Springer
Stem cell reviews and reports, 2017Springer
Mesenchymal stem cells (MSC) have been extensively studied over the past years for the
treatment of different diseases. Most of the ongoing clinical trials currently involve the use of
MSC derived from adult tissues. This source may have some limitations, particularly with
therapies that may require extensive and repetitive cell dosage. However, nowadays, there
is a staggering growth in literature on a new source of MSC. There is now increasing
evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we …
Abstract
Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repetitive cell dosage. However, nowadays, there is a staggering growth in literature on a new source of MSC. There is now increasing evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we summarize the current knowledge of pluripotent-derived mesenchymal stem cells (PD-MSC). We present a historical perspective on the subject, and then discuss some critical questions that remain unanswered.
Springer