[HTML][HTML] Autophagy protects proximal tubular cells from injury and apoptosis
GP Kaushal - Kidney international, 2012 - Elsevier
GP Kaushal
Kidney international, 2012•ElsevierAutophagy is upregulated during ischemia–reperfusion (IR)-induced and cisplatin-induced
acute kidney injury (AKI). Proximal tubule-specific Atg7 knockout mice exhibited increased
renal injury compared with wild-type mice following cisplatin-and IR-induced AKI. Inhibition
of autophagy by chloroquine aggravated AKI, whereas upregulation of autophagy by
rapamycin recovered lost renal function and histology, further indicating a protective role of
autophagy in AKI. These findings reported by Jiang et al. will provide stimulus to further …
acute kidney injury (AKI). Proximal tubule-specific Atg7 knockout mice exhibited increased
renal injury compared with wild-type mice following cisplatin-and IR-induced AKI. Inhibition
of autophagy by chloroquine aggravated AKI, whereas upregulation of autophagy by
rapamycin recovered lost renal function and histology, further indicating a protective role of
autophagy in AKI. These findings reported by Jiang et al. will provide stimulus to further …
Autophagy is upregulated during ischemia–reperfusion (IR)-induced and cisplatin-induced acute kidney injury (AKI). Proximal tubule-specific Atg7 knockout mice exhibited increased renal injury compared with wild-type mice following cisplatin- and IR-induced AKI. Inhibition of autophagy by chloroquine aggravated AKI, whereas upregulation of autophagy by rapamycin recovered lost renal function and histology, further indicating a protective role of autophagy in AKI. These findings reported by Jiang et al. will provide stimulus to further examine the role and mechanism of the enhancement of autophagy in AKI.
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