[HTML][HTML] Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase
M Haas, A Askari, Z Xie - Journal of Biological Chemistry, 2000 - ASBMB
Nontoxic concentrations of ouabain, causing partial inhibition of the cardiac myocyte Na+/K+-
ATPase, induce hypertrophy and several growth-related genes through signal pathways that
include the activation of Ras and p42/44 mitogen-activated protein kinase (MAPK). The aim
of this work was to examine the ouabain-induced events upstream of the Ras/MAPK
cascade. Treatment of myocytes with genistein antagonized ouabain-induced activation of
the MAPK, suggesting that protein tyrosine phosphorylation has a role. Tyrosine …
ATPase, induce hypertrophy and several growth-related genes through signal pathways that
include the activation of Ras and p42/44 mitogen-activated protein kinase (MAPK). The aim
of this work was to examine the ouabain-induced events upstream of the Ras/MAPK
cascade. Treatment of myocytes with genistein antagonized ouabain-induced activation of
the MAPK, suggesting that protein tyrosine phosphorylation has a role. Tyrosine …