Coexistence of systemic lupus erythematosus, tuberous sclerosis and aggressive natural killer-cell leukaemia: coincidence or correlated?
M Olde Bekkink, YM Ahmed-Ousenkova, MG Netea… - Lupus, 2016 - journals.sagepub.com
M Olde Bekkink, YM Ahmed-Ousenkova, MG Netea, WJ Van Der Velden, JH Berden
Lupus, 2016•journals.sagepub.comAmong patients with systemic lupus erythematosus (SLE) there is an increased risk of
haematological malignancies, especially non-Hodgkin lymphoma. However, the association
of SLE with aggressive CD3 negative natural killer (NK)-cell leukaemia has not been
reported so far. We present a case of a 39-year-old woman with SLE, aggressive NK-cell
leukaemia and tuberous sclerosis complex. The prior probability of developing the
combination of these three rare diseases by coincidence is extremely low (< 10− 13) …
haematological malignancies, especially non-Hodgkin lymphoma. However, the association
of SLE with aggressive CD3 negative natural killer (NK)-cell leukaemia has not been
reported so far. We present a case of a 39-year-old woman with SLE, aggressive NK-cell
leukaemia and tuberous sclerosis complex. The prior probability of developing the
combination of these three rare diseases by coincidence is extremely low (< 10− 13) …
Among patients with systemic lupus erythematosus (SLE) there is an increased risk of haematological malignancies, especially non-Hodgkin lymphoma. However, the association of SLE with aggressive CD3 negative natural killer (NK)-cell leukaemia has not been reported so far. We present a case of a 39-year-old woman with SLE, aggressive NK-cell leukaemia and tuberous sclerosis complex. The prior probability of developing the combination of these three rare diseases by coincidence is extremely low (<10−13). Possible underlying immunological, genetic and toxic/environmental pathways are discussed.
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