Association between the endogenous retrovirus HRES-1 and multiple sclerosis in the United Kingdom--evidence of genetically different disease subsets?
HB Rasmussen, MA Kelly, DA Francis… - Disease …, 2000 - content.iospress.com
HB Rasmussen, MA Kelly, DA Francis, J Clausen
Disease markers, 2000•content.iospress.comIn the present study we determined the frequencies of four haplotypes of the human T-cell
lymphotropic virus-related endogenous sequence, HRES-1, in 110 multiple sclerosis (MS)
patients and 100 healthy control subjects from the United Kingdom. We found evidence of
an association between this endogenous retrovirus and MS ([TeX:] p< 0.01), in particular
reflecting an increased frequency of HRES-1 haplotype 1 in the group of patients. There was
no significant difference in the distribution of HRES-1 haplotypes between relapsing …
lymphotropic virus-related endogenous sequence, HRES-1, in 110 multiple sclerosis (MS)
patients and 100 healthy control subjects from the United Kingdom. We found evidence of
an association between this endogenous retrovirus and MS ([TeX:] p< 0.01), in particular
reflecting an increased frequency of HRES-1 haplotype 1 in the group of patients. There was
no significant difference in the distribution of HRES-1 haplotypes between relapsing …
Abstract
In the present study we determined the frequencies of four haplotypes of the human T-cell lymphotropic virus-related endogenous sequence, HRES-1, in 110 multiple sclerosis (MS) patients and 100 healthy control subjects from the United Kingdom. We found evidence of an association between this endogenous retrovirus and MS ([TeX:] p< 0.01), in particular reflecting an increased frequency of HRES-1 haplotype 1 in the group of patients. There was no significant difference in the distribution of HRES-1 haplotypes between relapsing-remitting MS and the primary progressive form of the disease. The odds ratio for HRES-1 haplotype 1 and MS did not differ significantly between individuals positive for HLA-DR2 and DR2-negative individuals. Comparison of the observations from the present study with previous results implicated HRES-1 as a marker of genetic heterogeneity in MS.
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