[HTML][HTML] Retinal hypercholesterolemia triggers cholesterol accumulation and esterification in photoreceptor cells
A Saadane, N Mast, T Dao, B Ahmad… - Journal of Biological …, 2016 - ASBMB
The process of vision is impossible without the photoreceptor cells, which have a unique
structure and specific maintenance of cholesterol. Herein we report on the previously
unrecognized cholesterol-related pathway in the retina discovered during follow-up
characterizations of Cyp27a1−/− Cyp46a1−/− mice. These animals have retinal
hypercholesterolemia and convert excess retinal cholesterol into cholesterol esters,
normally present in the retina in very small amounts. We established that in the Cyp27a1 …
structure and specific maintenance of cholesterol. Herein we report on the previously
unrecognized cholesterol-related pathway in the retina discovered during follow-up
characterizations of Cyp27a1−/− Cyp46a1−/− mice. These animals have retinal
hypercholesterolemia and convert excess retinal cholesterol into cholesterol esters,
normally present in the retina in very small amounts. We established that in the Cyp27a1 …