Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles
CA Curcio, JB Presley, CL Millican… - Experimental eye …, 2005 - Elsevier
Neutral lipid, including esterified cholesterol, and apolipoproteins B and E are abundant in
basal deposits and drusen of aged and age-related maculopathy (ARM) eyes. The principal
component of basal linear deposit (BlinD), a specific ARM lesion, is membranous debris,
which if actually derived from membranes cannot account for extracellular neutral lipid. We
therefore used a lipid-preserving ultrastructural method to obtain improved images of
membranous debris. Maculas from 44 human donors (71–96yr) were preserved< 7· 5hr after …
basal deposits and drusen of aged and age-related maculopathy (ARM) eyes. The principal
component of basal linear deposit (BlinD), a specific ARM lesion, is membranous debris,
which if actually derived from membranes cannot account for extracellular neutral lipid. We
therefore used a lipid-preserving ultrastructural method to obtain improved images of
membranous debris. Maculas from 44 human donors (71–96yr) were preserved< 7· 5hr after …