KEAP1 has a sweet spot: a new connection between intracellular glycosylation and redox stress signaling in cancer cells
The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is
dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled
by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient
sensing, proteostasis and stress resistance in both normal and cancer cells.
dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled
by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient
sensing, proteostasis and stress resistance in both normal and cancer cells.
Abstract
The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient sensing, proteostasis and stress resistance in both normal and cancer cells.
Taylor & Francis Online