[HTML][HTML] AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation
WD Cheung, GW Hart - Journal of Biological Chemistry, 2008 - ASBMB
We have demonstrated previously that a wide array of stress signals induces O-GlcNAc
transferase (OGT) expression and increases O-GlcNAcylation of many intracellular proteins,
a response that is critical for cell survival. Here, we describe a mechanism by which glucose
deprivation induces OGT expression and activity in Neuro-2a neuroblastoma cells. Glucose
deprivation increases OGT mRNA and protein expression in an AMP-activated protein
kinase-dependent manner, whereas OGT enzymatic activity is regulated in a p38 MAPK …
transferase (OGT) expression and increases O-GlcNAcylation of many intracellular proteins,
a response that is critical for cell survival. Here, we describe a mechanism by which glucose
deprivation induces OGT expression and activity in Neuro-2a neuroblastoma cells. Glucose
deprivation increases OGT mRNA and protein expression in an AMP-activated protein
kinase-dependent manner, whereas OGT enzymatic activity is regulated in a p38 MAPK …