Phagocytosis and Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils

SD Kobayashi, AR Porter, DW Dorward… - The Journal of …, 2016 - academic.oup.com
SD Kobayashi, AR Porter, DW Dorward, AJ Brinkworth, L Chen, BN Kreiswirth, FR DeLeo
The Journal of infectious diseases, 2016academic.oup.com
Carbapenem-resistant Klebsiella pneumoniae strains classified as multilocus sequence
type 258 (ST258) are among the most widespread multidrug-resistant hospital-acquired
pathogens. Treatment of infections caused by these organisms is difficult, and mortality is
high. The basis for the success of ST258, outside of antibiotic resistance, remains
incompletely determined. Here we tested the hypothesis that ST258 K. pneumoniae has
enhanced capacity to circumvent killing by human neutrophils, the primary cellular defense …
Abstract
Carbapenem-resistant Klebsiella pneumoniae strains classified as multilocus sequence type 258 (ST258) are among the most widespread multidrug-resistant hospital-acquired pathogens. Treatment of infections caused by these organisms is difficult, and mortality is high. The basis for the success of ST258, outside of antibiotic resistance, remains incompletely determined. Here we tested the hypothesis that ST258 K. pneumoniae has enhanced capacity to circumvent killing by human neutrophils, the primary cellular defense against bacterial infections. There was limited binding and uptake of ST258 by human neutrophils, and correspondingly, there was limited killing of bacteria. On the other hand, transmission electron microscopy revealed that any ingested organisms were degraded readily within neutrophil phagosomes, thus indicating that survival in the neutrophil assays is due to limited phagocytosis, rather than to microbicide resistance after uptake. Our findings suggest that enhancing neutrophil phagocytosis is a potential therapeutic approach for treatment of infection caused by carbapenem-resistant ST258 K. pneumoniae.
Oxford University Press