Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative
disease that disproportionately affects young adults, leading to disability and high costs to
society. Infiltration of T cells and monocytes into the central nervous system (CNS) is critical
for disease initiation and progression. However, despite a great deal of effort the molecular
mechanisms by which immune cells initiate and perpetuate CNS damage in MS have not yet
been elucidated. In experimental autoimmune encephalomyelitis (EAE), an animal model of …