Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective

C Musso, E Cochran, SA Moran, MC Skarulis, EA Oral… - Medicine, 2004 - journals.lww.com
The interaction of insulin with its cell surface receptor is the first step in insulin action and the
first identified target of insulin resistance. The insulin resistance in several syndromic forms
of extreme insulin resistance has been shown to be caused by mutations in the receptor
gene.