The incidence and prevalence of diabetes mellitus are each increasing rapidly in our
society. The majority of patients with diabetes succumb ultimately to heart disease, much of
which stems from atherosclerotic disease and hypertension. However, cardiomyopathy can
develop independent of elevated blood pressure or coronary artery disease, a process
termed diabetic cardiomyopathy. This disorder is a complex diabetes-associated process
characterized by significant changes in the physiology, structure, and mechanical function of …