[HTML][HTML] Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary …

Y Zhou, JY Lee, CM Lee, WK Cho, MJ Kang… - Journal of Biological …, 2012 - ASBMB
Dysregulated amphiregulin (AR) expression and EGR receptor (EGFR) activation have been
described in animal models of pulmonary fibrosis and in patients with idiopathic pulmonary
fibrosis. However, the exact role of AR in the pathogenesis of pulmonary fibrosis has not
been clearly defined. Here, we show that a potent profibrogenic cytokine TGF-β1
significantly induced the expression of AR in lung fibroblasts in vitro and in murine lungs in
vivo. AR stimulated NIH3T3 fibroblast cell proliferation in a dose-dependent manner …