[HTML][HTML] Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2
T Yokomizo, K Kato, H Hagiya, T Izumi… - Journal of Biological …, 2001 - ASBMB
Leukotriene B 4, an arachidonate metabolite, is a potent chemoattractant of leukocytes
involved in various inflammatory diseases. Two G-protein-coupled receptors for leukotriene
B 4 have been cloned and characterized. BLT1 (Yokomizo, T., Izumi, T., Chang, K., Takuwa,
Y., and Shimizu, T.(1997) Nature 387, 620–624) is a high affinity receptor exclusively
expressed in leukocytes, and BLT2 (Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., and
Shimizu, T.(2000) J. Exp. Med. 192, 421–432) is a low affinity receptor expressed more …
involved in various inflammatory diseases. Two G-protein-coupled receptors for leukotriene
B 4 have been cloned and characterized. BLT1 (Yokomizo, T., Izumi, T., Chang, K., Takuwa,
Y., and Shimizu, T.(1997) Nature 387, 620–624) is a high affinity receptor exclusively
expressed in leukocytes, and BLT2 (Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., and
Shimizu, T.(2000) J. Exp. Med. 192, 421–432) is a low affinity receptor expressed more …