[HTML][HTML] 5-Lipoxygenase-mediated endogenous DNA damage
W Jian, SH Lee, MV Williams, IA Blair - Journal of biological chemistry, 2009 - ASBMB
Lipoxygenases (LOs) convert polyunsaturated fatty acids into lipid hydroperoxides.
Homolytic decomposition of lipid hydroperoxides gives rise to endogenous genotoxins such
as 4-oxo-2 (E)-nonenal, which cause the formation of mutagenic DNA adducts. Chiral
lipidomics analysis was employed to show that a 5-LO-derived lipid hydroperoxide was
responsible for endogenous DNA-adduct formation. The study employed human
lymphoblastoid CESS cells, which expressed both 5-LO and the required 5-LO-activating …
Homolytic decomposition of lipid hydroperoxides gives rise to endogenous genotoxins such
as 4-oxo-2 (E)-nonenal, which cause the formation of mutagenic DNA adducts. Chiral
lipidomics analysis was employed to show that a 5-LO-derived lipid hydroperoxide was
responsible for endogenous DNA-adduct formation. The study employed human
lymphoblastoid CESS cells, which expressed both 5-LO and the required 5-LO-activating …