A series of six derivatives of arachidonic acid containing a conjugated triene system and
hydroxyl groups at C-15 and at C-8 or C-14 (15-series leukotrienes) was isolated from
eosinophil-rich human leukocyte preparations. Among classes of leukocytes in these
preparations, eosinophils were the dominant source of the 15-series leukotrienes. The most
abundant arachidonate metabolite recovered from human eosinophils was 15 (S)-hydroxy-
5, 8, 11-cis-13-trans-eicosatetraenoic acid. This compound was synthesized by a …