Dendritic cells (DCs) are highly potent stimulators of the immune system, and their
contribution as such to the pathogenesis of corneal and ocular surface inflammatory disease
has been well established. These vigorous antigen-presenting cells are reliant upon their
effective migration from peripheral tissues (eg, those of the ocular surface) to the lymphoid
organs, where immune responses are triggered and can then cause disease. The
chemokine receptor CCR7 expressed on DCs has emerged as the master mediator of this …